Gene Therapy Looks Promising for Diabetic Retinopathy 

According to researchers, Gene Therapy might be a useful alternative for managing severe diabetic retinopathy. According to Charles Wykoff, MD, PhD, deputy chair of ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Texas, the treatment causes cells to produce an antivascular endothelial growth factor (VEGF) molecule that is identical to ranibizumab.

According to past trials, “from an efficacy perspective, we’re seeing what you would expect with regular anti-VEGF treatment,” Wykoff told Medscape Medical News. Additionally, he added, the procedure seems to be safe thus far. Wykoff presented early findings from the phase 2 ALTITUDE study of Regenxbio’s RGX-314 here at the American Society of Retina Specialists (ASRS) 2022 Annual Meeting.

Patients without diabetic macular edoema can successfully receive intravitreal injections of anti-VEGFs to treat very severe nonproliferative diabetic retinopathy. However, according to Wykoff, the illness continues to be the predominant reason for blindness in those who are working age.’

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